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Clostridioides difficile, more commonly referred to as C. diff, is a is a germ (bacterium) that causes diarrhea and colitis (an inflammation of the colon). According to the CDC, it’s estimated to cause almost half a million infections in the United States each year, and about 1 in 6 patients who get C. diff will get it again in the subsequent 2-8 weeks.
There has historically been an unmet need in treating C. diff., with the former standard of care being antibiotic treatment – a method that is ineffective against dormant spore forms of C. difficile, which can germinate and grow after antibiotics are completed, leading to cases of recurrence.